The Genetics Of Breast Cancer

Every woman runs the risk of getting breast cancer as she gets older, chances are veće.Šanse for breast cancer of women is 14 percent or one in every eight women, when you consider the lifespan of women, assuming a living until the age of about 90 years. If you feel that your life of 90 years, chances are 14 percent, you'll get bolest.Dobra news is that 86 percent will not get the disease.

How do genetics affect your chances of getting breast cancer?

Most cases of hereditary breast cancer are associated with two genes for breast cancer gene 1 (BRCA1) and breast cancer gene 2 (BRCA2). These two genes play a role in maintaining breast cells growing normally and to prevent any growth of cancerous cells. However, an abnormal BRCA 1 and BRCA2 genes increase the risk of an individual breast cancer. These genes typically comprise up to 10 percent of all cases of breast cancer.

While most women who have breast cancer have no family history of diabetes, women who are diagnosed with the disease and also have an abnormal BRCA1 or BRCA2 gene often women with a family history of disease.

These abnormal BRCA1 and BRCA2 genes may be acquired or inherited. Acquired is not inherited and the gene becomes abnormal as a result of errors in this gene plays, wear and tear, exposure to toxic materials, hormonal influences, diet, environmental factors, or sometimes even unknown factors. Inherited from parents, it is a normal gene from one parent and one abnormal gene from the other. They are born with this abnormal gene. 85 percent to 90 percent of breast cancers are the result of acquired genetic abnormalities.

chances that an individual will have an abnormal breast cancer gene are as follows:

. If an individual in the family suffers from both ovarian and breast cancer.

. If any individual's mother or paternal sister, aunt, mother or grandmother had breast cancer diagnosed before the age of 50 years.

. Female in each family had breast cancer.

. Women in some families had cancer in both her ​​breasts.

. If one is from Eastern Europe.

If an individual's mother or father has an abnormal breast cancer gene, the chances of passing the gene to which the individual is 50 posto.Šanse for an individual to pass on to their children is 25 percent, provided that the father does not have an abnormal gene. This does not necessarily mean that all family members will have an abnormal gene, if one family member has.

of men and breast cancer

Men are at increased risk of breast cancer if they inherit the abnormal gene for breast cancer. Through man's life, the risk is about 6 percent, which is about 80 times higher than for a man without abnormal breast cancer gene.

The study also found that men who have abnormal breast cancer gene are more likely to get prostate cancer than men who do not. This abnormal gene also has the same effect on the increased cancer of the digestive tract, or skin cancer.

Is Prophylactic Surgery Necessary To Prevent Breast Cancer?

Some women at high risk who were diagnosed with breast cancer consider prophylactic (preventive) surgery. It includes a mastectomy (breast removal), and can sometimes involve a complete hysterectomy (removal of uterus and ovaries). Although many studies have confirmed there is less breast cancer and ovarian cancer in women who have had these organs removed, subsequent studies have questioned the use of such radical preventive measures for quality-of-life issues and long-term side effects.

Since the introduction of prophylactic surgery, the medical community has failed to focus on the issues of surgical complications and risk communication for the benefit of informacija.Pretraživanje database of studies on preventive mastectomy for breast cancer prevention research revealed bias, poorly designed studies and inappropriate prequalified participants . Researchers who evaluated 23 studies involving more than 4,000 patients concluded in a report featured in The Cochrane Database System Review, which are more stringent and prospective research is needed, because "the state of science is far from accurate in predicting who will win or who will die from breast cancer. by one estimate, the majority of women considered at high risk for family history (but not necessarily BRCA1 or 2 mutation carriers) who have undergone these procedures would not have died from breast cancer. "researchers have reported that body image and feelings of femininity were negatively affected.

Although many genetic counseling and research institutions continue to promote this operation, the woman is advised to evaluate this decision carefully. Genetic testing is not designed to be a diagnostic tool. Although studies have confirmed that mutations in BRCA1 and BRCA2 genes cause a predisposition to breast and ovarian cancer, many other genes have been identified which may also increase the risk of women. Until more research is done, genetic testing should not be the only tool that is used to recommend a serious operation.

high-risk women with a family history of breast cancer or who have tested positive for mutations in BRCA1 and BRCA2 genes are advised to take an aggressive integrative prevention plan. In addition, those who take tamoxifen may derive additional protection of indole-3-carbinol (abundant in cruciferous vegetables) or supplemental diindolylmethane (DIM). Aggressive screening is also recommended for these women. This may involve a combination of mammography with ultrasound, and for those at risk for ovarian cancer, annual pelvic ultrasound. If the risk level is high, ask your doctor how you can accelerate your screening program.

Stage 4 Breast Cancer Survival Rate

the survival rate for stage four breast cancer, or what is called advanced breast cancer is significantly lower than that for any stage of breast cancer. This is because the cancer has grown and because it is spread, not only in the breast where it originated, but also in other parts of the breasts and other body parts, the main areas of the bone, lung and liver tissue.

Many medical experts feel that their research seems to indicate that the time of this cancer has reached stage four, it was attacked and overcome the body's natural defense system to the extent that what is called the five year survival rate was significantly decreased an average of sixteen up to twenty percent.
This opinion is supported by American Cancer Society.

Although this statistic is not written in stone, it is not fulfilled in any case, most women who are diagnosed with cancer when the cancer has reached the fourth stage, live, on average, for eighteen more months after initial diagnosis.

According to the American Cancer Society, their statistics seem to show that the number of women who live outside of the average and living five years after the original diagnosis of stage four breast cancer, and may live for another three and half years.

Breast cancer is a silent killer. It sneaks in on the person and invade your body, and often not recognized until it literally took a large part of the body, which leads to the necessity of very aggressive treatments.

Do not wait for breast cancer took her body to fight natrag.Najbolji defense is a good offensive. Check your breasts for lumps on a regular monthly basis. If you discover a lump, get it checked immediately. Are regular clinical breast examinations, including mammograms. According to the American Cancer Society, this happens every three years for women between the ages of twenty to forty years, and every year for women past forty years.

Do not wait for breast cancer invade my body. If it does not appear, be ready to catch early. If you do not catch an early, if you do not get to stage four, and then fight smart and aggressive and not give up. Statistics are just that, they are not written in stone and can not predict your future. To quote Mr. Spock, "Live long and prospter